Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide.
Identifieur interne : 006772 ( Main/Exploration ); précédent : 006771; suivant : 006773Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide.
Auteurs : Musheng Bao [République populaire de Chine] ; Yi Zhang ; Min Wan ; Li Dai ; Xiaoping Hu ; Xiuli Wu ; Li Wang ; Ping Deng ; Junzhi Wang ; Jianzhu Chen ; Yongjun Liu ; Yongli Yu ; Liying WangSource :
- Clinical immunology (Orlando, Fla.) [ 1521-6616 ]
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Adjuvants immunologiques (pharmacologie), Agranulocytes (immunologie), Agranulocytes (virologie), Animaux, Antiviraux (pharmacologie), Cellules Vero, Cellules tueuses naturelles (immunologie), Cellules tueuses naturelles (virologie), Humains, Ilots CpG (immunologie), Lignée cellulaire, Lymphocytes B (immunologie), Lymphocytes B (virologie), Oligodésoxyribonucléotides (immunologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Tests de cytotoxicité immunologique, Virus du SRAS (immunologie).
- MESH :
- immunologie : Activation des lymphocytes, Agranulocytes, Cellules tueuses naturelles, Ilots CpG, Lymphocytes B, Oligodésoxyribonucléotides, Syndrome respiratoire aigu sévère, Virus du SRAS.
- pharmacologie : Adjuvants immunologiques, Antiviraux.
- virologie : Agranulocytes, Cellules tueuses naturelles, Lymphocytes B.
- Animaux, Cellules Vero, Humains, Lignée cellulaire, Syndrome respiratoire aigu sévère, Tests de cytotoxicité immunologique.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (pharmacology), Animals, Antiviral Agents (pharmacology), B-Lymphocytes (immunology), B-Lymphocytes (virology), Cell Line, Chlorocebus aethiops, CpG Islands (immunology), Cytotoxicity Tests, Immunologic, Humans, Killer Cells, Natural (immunology), Killer Cells, Natural (virology), Leukocytes, Mononuclear (immunology), Leukocytes, Mononuclear (virology), Lymphocyte Activation (immunology), Oligodeoxyribonucleotides (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Vero Cells.
- MESH :
- chemical , immunology : Oligodeoxyribonucleotides.
- chemical , pharmacology : Adjuvants, Immunologic, Antiviral Agents.
- immunology : B-Lymphocytes, CpG Islands, Killer Cells, Natural, Leukocytes, Mononuclear, Lymphocyte Activation, SARS Virus, Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : B-Lymphocytes, Killer Cells, Natural, Leukocytes, Mononuclear.
- Animals, Cell Line, Chlorocebus aethiops, Cytotoxicity Tests, Immunologic, Humans, Vero Cells.
Abstract
To develop CpG oligodeoxynucleotides (CpG ODNs) based therapy for prevention and treatment of severe acute respiratory syndrome (SARS), we selected a novel CpG ODN (BW001), which displays B-type CpG ODN structure feature at the 5' and A-type CpG ODN structure feature at the 3', and tested for its anti-SARS-CoV activity. We found that the supernatants of human PBMCs stimulated by BW001 significantly protected Vero cells from SARS-CoV infection. BW001 could stimulate human PBMCs and pDCs to secrete high level of IFN-alpha and promote human PBMCs and B cells to proliferate. Furthermore, we demonstrated that BW001 could activate CD19+ B cells and CD56+ NK cells in human PBMCs. In addition, BW001 could enhance NK cytotoxicity and IFN-gamma secretion in human PBMCs. Together, BW001 represents a novel type of CpG ODN and may have potential for the development of treatment and prevention for SARS as well as other viral associated diseases.
DOI: 10.1016/j.clim.2005.09.014
PubMed: 16298165
Affiliations:
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Le document en format XML
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<term>B-Lymphocytes (virology)</term>
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<term>Adjuvants immunologiques (pharmacologie)</term>
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<term>Cellules tueuses naturelles</term>
<term>Ilots CpG</term>
<term>Lymphocytes B</term>
<term>Oligodésoxyribonucléotides</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
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<term>CpG Islands</term>
<term>Killer Cells, Natural</term>
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<term>Lymphocyte Activation</term>
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<front><div type="abstract" xml:lang="en">To develop CpG oligodeoxynucleotides (CpG ODNs) based therapy for prevention and treatment of severe acute respiratory syndrome (SARS), we selected a novel CpG ODN (BW001), which displays B-type CpG ODN structure feature at the 5' and A-type CpG ODN structure feature at the 3', and tested for its anti-SARS-CoV activity. We found that the supernatants of human PBMCs stimulated by BW001 significantly protected Vero cells from SARS-CoV infection. BW001 could stimulate human PBMCs and pDCs to secrete high level of IFN-alpha and promote human PBMCs and B cells to proliferate. Furthermore, we demonstrated that BW001 could activate CD19+ B cells and CD56+ NK cells in human PBMCs. In addition, BW001 could enhance NK cytotoxicity and IFN-gamma secretion in human PBMCs. Together, BW001 represents a novel type of CpG ODN and may have potential for the development of treatment and prevention for SARS as well as other viral associated diseases.</div>
</front>
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<name sortKey="Deng, Ping" sort="Deng, Ping" uniqKey="Deng P" first="Ping" last="Deng">Ping Deng</name>
<name sortKey="Hu, Xiaoping" sort="Hu, Xiaoping" uniqKey="Hu X" first="Xiaoping" last="Hu">Xiaoping Hu</name>
<name sortKey="Liu, Yongjun" sort="Liu, Yongjun" uniqKey="Liu Y" first="Yongjun" last="Liu">Yongjun Liu</name>
<name sortKey="Wan, Min" sort="Wan, Min" uniqKey="Wan M" first="Min" last="Wan">Min Wan</name>
<name sortKey="Wang, Junzhi" sort="Wang, Junzhi" uniqKey="Wang J" first="Junzhi" last="Wang">Junzhi Wang</name>
<name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name>
<name sortKey="Wang, Liying" sort="Wang, Liying" uniqKey="Wang L" first="Liying" last="Wang">Liying Wang</name>
<name sortKey="Wu, Xiuli" sort="Wu, Xiuli" uniqKey="Wu X" first="Xiuli" last="Wu">Xiuli Wu</name>
<name sortKey="Yu, Yongli" sort="Yu, Yongli" uniqKey="Yu Y" first="Yongli" last="Yu">Yongli Yu</name>
<name sortKey="Zhang, Yi" sort="Zhang, Yi" uniqKey="Zhang Y" first="Yi" last="Zhang">Yi Zhang</name>
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<country name="République populaire de Chine"><region name="Jilin"><name sortKey="Bao, Musheng" sort="Bao, Musheng" uniqKey="Bao M" first="Musheng" last="Bao">Musheng Bao</name>
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